Analytical Data
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Gene name
HAUS4
- Application
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Alternative Names
HAUS4；C14orf94；HAUS augmin-like complex subunit 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H6D7
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Expression Region
1-363aa
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AA Sequence
MASGDFCSPGEGMEILQQVCSKQLPPCNLSKEDLLQNPYFSKLLLNLSQHVDESGLSLTLAKEQAQAWKEVRLHKTTWLRSEILHRVIQELLVDYYVKIQDTNVTSEDKKFHETLEQRLLVTELMRLLGPSQEREIPPLLGLEKADLLELMPLSEDFVWMRARLQQEVEEQLKKKCFTLLCYYDPNSDADSETVKAAKVWKLAEVLVGEQQQCQDAKSQQKEQMLLLEKKSAAYSQVLLRCLTLLQRLLQEHRLKTQSELDRINAQYLEVKCGAMILKLRMEELKILSDTYTVEKVEVHRLIRDRLEGAIHLQEQDMENSRQVLNSYEVLGEEFDRLVKEYTVLKQATENKRWALQEFSKVYR
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Molecular Weight
69.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HAUS4, a crucial component of the HAUS (Human Augmin-like) complex, plays a pivotal role in the regulation of microtubule dynamics during cell division, specifically in the formation of the mitotic spindle. This protein is part of a larger family involved in the assembly of the γ-tubulin ring complex, which is essential for microtubule nucleation. Recent studies have highlighted HAUS4's role in ensuring proper chromosome segregation and its impacts on cellular processes, including proliferation and tumorigenesis. Dysregulation of HAUS4 has been linked to various cancers, underscoring its potential as a biomarker and a therapeutic target. Understanding the molecular mechanisms underlying HAUS4 function could provide insights into mitotic errors and their implications in cancer biology, thereby contributing to the development of novel treatment strategies aimed at cell division-related disorders. Researchers are increasingly focused on elucidating the structural properties of HAUS4, its interaction with other proteins in the HAUS complex, and its modulation by cellular signaling pathways. This research is significant not only for its basic biological insights but also for its potential applications in cancer therapeutics, making HAUS4 a promising candidate for further investigation.
