Analytical Data
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基因名
SOCS6
- Application
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别名
SOCS-6;Cytokine-inducible SH2 protein 4;CIS-4;Suppressor of cytokine signaling 4;SOCS-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
SOCS6
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表达区间
1-535 aa
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氨基酸序列
MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
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分子量
65.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOCS6 (Suppressor of Cytokine Signaling 6) is a member of the SOCS family of proteins, which are critical negative regulators of cytokine signaling pathways. These proteins play a significant role in modulating immune responses and cellular processes by inhibiting the signal transducer and activator of transcription (STAT) pathway, among others. Research into SOCS6 has gained momentum due to its involvement in various physiological and pathological conditions, including inflammatory responses, hematopoiesis, and cancer progression. Increasing evidence suggests that SOCS6 may contribute to the regulation of key signaling pathways, such as the insulin signaling pathway and those associated with cell proliferation and differentiation. Additionally, aberrant expression of SOCS6 has been linked to tumorigenesis, highlighting its potential as a therapeutic target in oncology. To better understand its functional mechanisms and interactions within the signaling networks, the recombinant expression of SOCS6 has become a crucial research focus. By producing SOCS6 in a controlled laboratory setting, scientists can investigate its structure, post-translational modifications, and binding affinities with other proteins, which can elucidate the role SOCS6 plays in cellular signaling. Furthermore, the ability to manipulate SOCS6 levels in vitro allows researchers to explore its potential as a biomarker for disease progression and response to therapies. Overall, SOCS6 stands out as a key player in cytokine signaling regulation, and the ongoing studies on its recombinant protein present promising avenues for both fundamental research and clinical applications.
