Analytical Data
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基因名
SLC2A2
- Application
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别名
liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; Glucose transporter. liver/islet; GLUT-2; GLUT2; GTR2_HUMAN; GTT2; SLC2A2; Solute carrier family 2 (facilitated glucose transporter) member 2; Solute carrier family 2 facilitated glucose transporter member 2; Solute carrier family 2. facilitated glucose transporter member 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11168
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表达区间
1-351 aa
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氨基酸序列
MYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
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分子量
65.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC2A2 (Solute Carrier Family 2 Member 2), also known as GLUT2, is a crucial glucose transporter primarily expressed in pancreatic beta cells, liver, and kidneys. It plays a vital role in glucose homeostasis and insulin secretion, influencing metabolic processes. Researchers have increasingly focused on SLC2A2 due to its implications in diabetes and metabolic disorders. Abnormal functioning or regulation of this transporter is linked to various pathophysiological conditions, including insulin resistance and Type 2 diabetes. Recent studies have highlighted the significance of SLC2A2 in glucose sensing and its potential as a therapeutic target for diabetes management. The development of recombinant SLC2A2 proteins is essential for elucidating the transport mechanism and regulatory pathways of this transporter, providing insights into its structure-function relationships. Additionally, these recombinant proteins facilitate the exploration of drug interactions and potential inhibitors, which can be pivotal in designing novel therapeutic strategies. Understanding the molecular dynamics of SLC2A2 through recombinant protein studies holds promise for advancing diabetes research and improving treatment modalities. Through techniques such as cryo-electron microscopy and site-directed mutagenesis, researchers aim to construct detailed models of SLC2A2, thus paving the way for innovative approaches to modulate its activity in disease contexts. Overall, the investigation of SLC2A2 recombinant proteins represents a significant step towards unveiling the complexities of glucose transport mechanisms and their implications for metabolic health.
