Analytical Data
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Gene name
SLC2A2
- Application
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Alternative Names
liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; Glucose transporter. liver/islet; GLUT-2; GLUT2; GTR2_HUMAN; GTT2; SLC2A2; Solute carrier family 2 (facilitated glucose transporter) member 2; Solute carrier family 2 facilitated glucose transporter member 2; Solute carrier family 2. facilitated glucose transporter member 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11168
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Expression Region
1-351 aa
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AA Sequence
MYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
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Molecular Weight
65.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC2A2 (Solute Carrier Family 2 Member 2), also known as GLUT2, is a crucial glucose transporter primarily expressed in pancreatic beta cells, liver, and kidneys. It plays a vital role in glucose homeostasis and insulin secretion, influencing metabolic processes. Researchers have increasingly focused on SLC2A2 due to its implications in diabetes and metabolic disorders. Abnormal functioning or regulation of this transporter is linked to various pathophysiological conditions, including insulin resistance and Type 2 diabetes. Recent studies have highlighted the significance of SLC2A2 in glucose sensing and its potential as a therapeutic target for diabetes management. The development of recombinant SLC2A2 proteins is essential for elucidating the transport mechanism and regulatory pathways of this transporter, providing insights into its structure-function relationships. Additionally, these recombinant proteins facilitate the exploration of drug interactions and potential inhibitors, which can be pivotal in designing novel therapeutic strategies. Understanding the molecular dynamics of SLC2A2 through recombinant protein studies holds promise for advancing diabetes research and improving treatment modalities. Through techniques such as cryo-electron microscopy and site-directed mutagenesis, researchers aim to construct detailed models of SLC2A2, thus paving the way for innovative approaches to modulate its activity in disease contexts. Overall, the investigation of SLC2A2 recombinant proteins represents a significant step towards unveiling the complexities of glucose transport mechanisms and their implications for metabolic health.
