Analytical Data
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Gene name
CTNNA3
- Application
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Alternative Names
4930429L08Rik; 4933408A16; Alpha catenin like protein; Alpha T catenin; Alpha T-catenin; Cadherin associated protein ; Cadherin-associated protein; Catenin alpha 3; Catenin alpha-3; Catna3; CTNA3_HUMAN; CTNNA3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UI47
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Expression Region
1-376aa
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AA Sequence
MSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQEATVLKDELTASLEKVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDVASLKASKDTVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNLCNQKSDLGLTGVKIKLLEECIIFWSL
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Molecular Weight
67.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CTNNA3, or Catenin Alpha 3, is a member of the catenin family, which plays a crucial role in cell adhesion, signaling, and cytoskeletal organization. It is predominantly expressed in the brain and has been implicated in various neurological processes. Research has indicated that CTNNA3 is involved in the regulation of synaptic plasticity and neuronal connectivity, making it a potential player in the pathogenesis of neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorders and schizophrenia. Furthermore, mutations and dysregulation of CTNNA3 have been associated with increased susceptibility to these conditions. Given its critical role in neuronal function, CTNNA3 has become a target for studying the molecular mechanisms underlying these disorders. The development of recombinant CTNNA3 proteins is pivotal for elucidating its biological functions and interactions in cellular pathways. This includes investigating its binding partners, participation in cellular adhesion processes, and impact on cell signaling pathways. Understanding the structure and function of CTNNA3 through recombinant protein studies may also lead to novel therapeutic strategies for neurological conditions linked to its aberrant expression or function. As such, the research of CTNNA3 recombinant proteins is not only essential for advancing our fundamental knowledge of synaptic biology but also for contributing to potential clinical implications in neurodevelopmental and neuropsychiatric conditions.
