Analytical Data
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基因名
HTR2A
- Application
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别名
HTR2A；HTR2；5-hydroxytryptamine receptor 2A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28223
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表达区间
1-471aa
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氨基酸序列
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The HTR2A gene encodes the serotonin receptor 2A, a key player in the serotonergic system that mediates various physiological and neurological processes. Dysregulation of HTR2A has been implicated in a range of psychiatric disorders, including schizophrenia, depression, and anxiety. Understanding the structure and function of HTR2A is crucial for elucidating its role in these conditions and for the development of targeted pharmacotherapies. The research on recombinant HTR2A proteins involves producing and characterizing this receptor in a controlled environment, facilitating studies on its ligand-binding properties, signaling mechanisms, and interactions with various pharmacological agents. Advances in recombinant protein techniques enable the production of active HTR2A proteins in cell systems, allowing for high-throughput screening and structure-function analysis. This work not only enhances our understanding of serotonin signaling but also paves the way for designing novel therapeutics aimed at modulating HTR2A activity, which could lead to improved treatments for various mood and psychotic disorders.
