Analytical Data
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Gene name
CPNE2
- Application
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Alternative Names
CPNE2Copine-2; Copine II
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FN4
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Expression Region
1-548aa
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AA Sequence
MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
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Molecular Weight
87.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CPNE2 (Copine 2) is a member of the copine family, characterized by its unique structure that includes two homologous C2 domains and a young domain, which are thought to be involved in calcium-dependent membrane interactions. Research on CPNE2 has garnered attention due to its emerging role in various physiological processes, including neuronal signaling, cell migration, and apoptosis. Its expression is primarily observed in the brain, indicating potential implications in neurodevelopmental and neurodegenerative disorders. Studies have suggested that CPNE2 may act as a regulatory protein at synapses, influencing neurotransmitter release and synaptic plasticity, which are critical for learning and memory. Moreover, dysregulation of CPNE2 has been associated with several diseases, highlighting its importance as a potential biomarker or therapeutic target. The recombinant production of CPNE2 is pivotal for elucidating its structural and functional properties, allowing researchers to investigate its interaction with membranes and other cellular components. By generating CPNE2 in a recombinant system, researchers can explore its biochemical characteristics, assess its role in cell signaling pathways, and evaluate its potential applications in drug development and regenerative medicine. Overall, the study of CPNE2 is crucial for advancing our understanding of cellular processes in health and disease, making it a significant focus of ongoing research in molecular and cellular biology.
