Analytical Data
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基因名
map-1
- Application
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别名
map-1;BPY2IP1;C19orf5;MAP8;Microtubule-associated Protein 1S
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P27361
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表达区间
2-379aa
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氨基酸序列
AAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
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分子量
50.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MAP-1 protein, known as microtubule-associated protein 1, has garnered significant attention in the field of cellular biology due to its crucial role in the regulation of microtubule dynamics and stability. Research surrounding MAP-1 has revealed its involvement in various cellular processes, including intracellular transport, cell shape maintenance, and neuronal development. Abnormalities in MAP-1 expression and function have been linked to several neurodegenerative diseases, such as Alzheimer's and Huntington's, highlighting its importance in maintaining neuronal integrity. The MAP-1 protein is composed of multiple isoforms, with MAP-1A and MAP-1B being the most studied variants, each playing distinct roles in the organization of the cytoskeleton. Recent advancements in techniques such as CRISPR/Cas9 gene editing and advanced imaging have facilitated deeper insights into MAP-1 function at both the cellular and molecular levels. Additionally, understanding the post-translational modifications of MAP-1, including phosphorylation, acetylation, and ubiquitination, has opened new avenues for exploring its regulatory mechanisms. As researchers continue to investigate the diverse roles of MAP-1, its potential as a therapeutic target for neurodegenerative and other diseases becomes increasingly clear, positioning it as a focal point for future studies aimed at developing novel intervention strategies. The continued exploration of MAP-1's structure, function, and interactions within the cellular context remains a promising frontier in biomedical research, with the potential to yield significant insights into both fundamental biology and disease pathology.












