Analytical Data
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Gene name
map-1
- Application
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Alternative Names
map-1；BPY2IP1；C19orf5；MAP8；Microtubule-associated Protein 1S
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P27361
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Expression Region
2-379aa
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AA Sequence
AAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
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Molecular Weight
50.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MAP-1 protein, known as microtubule-associated protein 1, has garnered significant attention in the field of cellular biology due to its crucial role in the regulation of microtubule dynamics and stability. Research surrounding MAP-1 has revealed its involvement in various cellular processes, including intracellular transport, cell shape maintenance, and neuronal development. Abnormalities in MAP-1 expression and function have been linked to several neurodegenerative diseases, such as Alzheimer's and Huntington's, highlighting its importance in maintaining neuronal integrity. The MAP-1 protein is composed of multiple isoforms, with MAP-1A and MAP-1B being the most studied variants, each playing distinct roles in the organization of the cytoskeleton. Recent advancements in techniques such as CRISPR/Cas9 gene editing and advanced imaging have facilitated deeper insights into MAP-1 function at both the cellular and molecular levels. Additionally, understanding the post-translational modifications of MAP-1, including phosphorylation, acetylation, and ubiquitination, has opened new avenues for exploring its regulatory mechanisms. As researchers continue to investigate the diverse roles of MAP-1, its potential as a therapeutic target for neurodegenerative and other diseases becomes increasingly clear, positioning it as a focal point for future studies aimed at developing novel intervention strategies. The continued exploration of MAP-1's structure, function, and interactions within the cellular context remains a promising frontier in biomedical research, with the potential to yield significant insights into both fundamental biology and disease pathology.
