Analytical Data
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基因名
COL4A6
- Application
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别名
COL4A6Collagen alpha-6(IV) chain
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14031
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表达区间
1-73aa
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氨基酸序列
MLINKLWLLLVTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGARHNLQLLNDMAGRLYHFSEVLPNLF
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分子量
33.77 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL4A6, a gene encoding for a member of the collagen IV family, is crucial for the structural integrity and function of basement membranes. Mutations in COL4A6 are associated with several health conditions, including Alport syndrome and other forms of kidney disease, highlighting its importance in nephrology and urology. Research has shown that COL4A6 plays a significant role in kidney filtration, providing insights into the pathophysiology of associated diseases. The recombinant protein of COL4A6 offers a valuable tool for studying its structure-function relationships and understanding the molecular mechanisms underlying related disorders. By producing COL4A6 in a controlled environment, researchers can investigate its properties, interactions with other extracellular matrix components, and its role in cellular processes. Moreover, recombinant COL4A6 can serve as a potential therapeutic target or biomarker, enhancing our understanding of kidney disease mechanisms and aiding in the development of novel treatment strategies. The growing body of research around COL4A6 underscores its significance in biomedical fields, making it a focal point for both fundamental research and clinical applications related to collagen disorders.
