Analytical Data
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Gene name
SRC
- Application
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Alternative Names
SRC；SRC1；Proto-oncogene tyrosine-Protein kinase Src
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P12931
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Expression Region
2-536aa
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AA Sequence
MHHHHHHGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASA DGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYD YESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF DNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYM SKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAAN ILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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Molecular Weight
61 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SRC (Avian Sarcoma Viral Oncogene Homolog) is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including proliferation, differentiation, and survival. Initially identified as an oncogene in relation to avian sarcoma viruses, SRC has been implicated in several human cancers, highlighting its significance in tumor biology and metastasis. Research on SRC recombinant proteins has gained momentum due to their potential as therapeutic targets and biomarkers. SRC's enzymatic activity is regulated by complex signaling pathways, making it a critical player in cellular communication and response to external stimuli. Understanding the structure and function of SRC through recombinant protein studies can reveal insights into its regulatory mechanisms and interactions with other cellular components. Furthermore, the development of SRC inhibitors has emerged as a promising strategy for cancer treatment, emphasizing the need for detailed studies on its biochemical properties. As SRC is often overexpressed or hyperactivated in cancer cells, targeted therapies aiming to inhibit this kinase hold potential for improving treatment outcomes. Researchers are employing various techniques to produce and characterize SRC recombinant proteins, enabling the exploration of its role in disease pathology and the identification of novel therapeutic approaches. Overall, the study of SRC recombinant proteins is pivotal in advancing our understanding of cancer biology and developing innovative strategies for intervention.
