Analytical Data
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基因名
DAPK1
- Application
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别名
DAPK1；DAPK；Death-associated Protein kinase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53355
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表达区间
2-363aa
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氨基酸序列
TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKS SRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGEL FDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRN VPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMW SIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF IRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAA RKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHA INDDNVPGLQHL
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分子量
67 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DAPK1 (Death-Associated Protein Kinase 1) is a serine/threonine kinase that plays a crucial role in various cellular processes, including apoptosis, autophagy, and cellular response to stress. It is particularly significant in the regulation of tumor suppression and has been implicated in the pathogenesis of various cancers. Research has shown that DAPK1 is often downregulated or inactivated in malignant tumors, contributing to tumor progression and resistance to therapy. The study of DAPK1 recombinant proteins is essential for understanding its functional mechanisms and interactions with other cellular pathways. By producing DAPK1 as a recombinant protein, researchers can investigate its enzymatic activity, identify potential substrates, and explore its role in signaling pathways associated with cancer. Additionally, recombinant DAPK1 can be utilized as a tool for drug discovery, enabling the screening of small molecules that may activate or inhibit its activity. The therapeutic potential of targeting DAPK1 in cancer treatment has garnered increasing interest, making it a significant focus for ongoing research. Insights obtained from DAPK1 recombinant protein studies may lead to the development of novel therapeutic strategies aimed at enhancing cancer cell sensitivity to treatment while further elucidating its role in normal cellular functions.
