Analytical Data
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基因名
RET
- Application
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别名
RET；CDHF12；CDHR16；PTC；Proto-oncogene tyrosine-Protein kinase receptor Ret
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07949
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表达区间
658-1114aa
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氨基酸序列
HCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVD AFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAV KMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK MMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWI ENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAK LMDTFDS
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分子量
74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RET (REarranged during Transfection) protein is a receptor tyrosine kinase that plays a critical role in various cellular processes, including cell differentiation, proliferation, and survival. Initially identified as a proto-oncogene implicated in certain cancers, such as multiple endocrine neoplasia type 2 (MEN2), RET has garnered significant attention due to its involvement in neurodevelopmental pathways, particularly in the formation of the enteric nervous system and the development of certain types of neural crest-derived tissues. Mutations and rearrangements in the RET gene can lead to aberrant signaling pathways, contributing to oncogenesis in several tumor types, including medullary thyroid carcinoma and papillary thyroid carcinoma. Consequently, the study of RET and its synthesized recombinant proteins has become a focus for researchers aiming to develop targeted therapies and diagnostic tools. Creating recombinant RET proteins has advanced our understanding of its structure-function relationships, ligand interactions, and downstream signaling mechanisms. Moreover, RET has emerged as a promising therapeutic target, with small molecule inhibitors showing potential in cancer treatment, thus underscoring the importance of ongoing research into the biology of RET and its implications in both health and disease. Understanding RET's mechanisms will ultimately aid in designing more effective interventions for RET-related malignancies and improve patient outcomes.
