Analytical Data
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基因名
SGCE
- Application
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别名
SGCE; ESG; UNQ433/PRO840; Epsilon-sarcoglycan; Epsilon-SG
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43556
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表达区间
1-437 aa
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氨基酸序列
MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP
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分子量
76.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research background of SGCE (sarcoglycan epsilon) recombinant protein is rooted in the pursuit of understanding and addressing muscular dystrophies, particularly the associated genetic disorders that impact muscle function. SGCE is part of the sarcoglycan complex, which plays a crucial role in maintaining the structural integrity of muscle fibers. Mutations in the SGCE gene can lead to a form of muscular dystrophy known as myoclonus-dystonia syndrome, characterized by muscle spasms, movement disorders, and progressive muscle weakness. Given the significance of SGCE in muscle physiology, scientists have focused on developing recombinant SGCE proteins to explore their structural properties and functional mechanisms in detail. This research aims to elucidate the pathophysiology of SGCE-related conditions and to potentially devise gene therapy approaches that could correct the underlying genetic defects. Additionally, recombinant SGCE proteins serve as valuable tools in drug development, enabling researchers to screen for therapeutic compounds that could enhance muscle functions or counteract the deleterious effects of SGCE mutations. Overall, the study of SGCE recombinant proteins is crucial for advancing our understanding of muscular dystrophies and developing innovative therapeutic strategies to improve the quality of life for affected individuals.
