Analytical Data
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基因名
CNO
- Application
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别名
BLOC1S4; CNOBiogenesis of lysosome-related organelles complex 1 subunit 4; BLOC-1 subunit 4; Protein cappuccino homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NUP1
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表达区间
1-217aa
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氨基酸序列
MEGSFSDGGA LPEGLAEEAE PQGAAWSGDS GTVSQSHSSA SGPWEDEGAE DGAPGRDLPL LRRAAAGYAA CLLPGAGARP EVEALDASLE DLLTRVDEFV GMLDMLRGDS SHVVSEGVPR IHAKAAEMRR IYSRIDRLEA FVRMVGGRVA RMEEQVTKAE AELGTFPRAF KKLLHTMNVP SLFSKSAPSR PQQAGYEAPV LFRTEDYFPC CSERPQL
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分子量
23.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNO, or the cyclin-dependent kinase inhibitor p18, is a crucial protein that plays a significant role in cell cycle regulation and differentiation. Its study has gained prominence due to its involvement in various cellular processes, including the inhibition of cyclin-dependent kinases (CDKs), which are essential for cell division. Dysregulation of CDK activity is associated with numerous diseases, particularly cancer, making CNO a potential target for therapeutic interventions. Research into the structure and function of CNO has revealed its intricate regulatory mechanisms, as well as its interactions with other cellular proteins. Understanding the nuances of CNO’s role in cellular physiology can provide insights into the underlying pathways involved in tumorigenesis and help in the development of novel cancer treatments. Additionally, the exploration of CNO as a recombinant protein has opened avenues for biotechnological applications, such as the development of diagnostic tools and targeted therapies. As the field progresses, the focus on CNO and its related pathways will likely yield significant advancements in both basic and applied biomedical research.
