Analytical Data
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基因名
ACVR1
- Application
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别名
ACVR1；ACVRLK2；Activin receptor type-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q04771
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表达区间
147-509aa
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氨基酸序列
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGL PFLVQRTVAHQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWF RETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQ LTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKK NGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLT KIDNSLDKLKTDC
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分子量
67 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR1 (Activin A receptor type I) is a crucial component of the bone morphogenetic protein (BMP) signaling pathway, primarily associated with the regulation of bone and soft tissue development. Mutations in the ACVR1 gene have been linked to several disorders, most notably Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic condition characterized by abnormal bone growth in soft tissues. The study of recombinant ACVR1 proteins has gained significant interest in the fields of developmental biology and regenerative medicine, as understanding the signaling mechanisms involves deciphering how ACVR1 interacts with its ligands. Recombinant ACVR1 proteins can be used to probe the functional assays necessary for identifying potential therapeutic targets and for exploring the pathway's role in ectopic bone formation. Furthermore, investigations into the binding affinities and functional consequences of ACVR1 mutations have implications for drug design aimed at inhibiting aberrant signaling pathways associated with FOP and other skeletal disorders. Thus, research on ACVR1 recombinant proteins not only enhances our understanding of fundamental biological processes but also holds promise for advancing treatment strategies in conditions related to abnormal bone growth.
