Analytical Data
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基因名
RBBP7
- Application
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别名
RBBP7；RBAP46；Histone-binding Protein RBBP7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16576
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表达区间
1-425aa
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氨基酸序列
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLP EVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSD KGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLV FDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHT VCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQK LMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIG EEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQI WQMAENIYNDEESDVTTSELEGQGS
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分子量
73 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBBP7 (Retinoblastoma Binding Protein 7) is a crucial multifunctional protein that has garnered significant attention in cancer research due to its role in cell cycle regulation and tumor suppression. It is a key component of various chromatin remodeling complexes and is involved in the regulation of gene expression, particularly in the context of the retinoblastoma tumor suppressor pathway. Dysregulation of RBBP7 has been associated with several malignancies, highlighting its potential as a biomarker for tumor progression and as a target for therapeutic intervention. The development of recombinant RBBP7 protein is critical for elucidating its structure-function relationships, understanding its interactions with other cellular components, and determining its precise roles in oncogenesis. By utilizing recombinant DNA technology, researchers can produce RBBP7 in a controlled manner, allowing for detailed biochemical and structural studies. This research not only contributes to the fundamental knowledge of tumor biology but also opens avenues for the development of innovative cancer therapies that could manipulate RBBP7's activity, potentially leading to more effective treatments for cancer patients.
