Analytical Data
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Gene name
CIRH1A
- Application
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Alternative Names
UTP4; CIRH1A; cPERP-E; KIAA1988U3 small nucleolar RNA-associated protein 4 homolog; Cirhin; UTP4 small subunit processome component
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969X6
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Expression Region
1-686aa
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AA Sequence
MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT
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Molecular Weight
101.2 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CIRH1A, or circadian rhythm-1A, is a protein that has garnered significant attention in recent years due to its crucial role in circadian rhythms and cellular functions. It is primarily involved in the regulation of gene expression related to the circadian clock, influencing various physiological processes including sleep-wake cycles, hormone secretion, and metabolic functions. Disruption of CIRH1A function has been implicated in various disorders such as sleep disorders, metabolic syndromes, and even certain types of cancer, highlighting its potential as a therapeutic target. Additionally, CIRH1A interacts with numerous proteins and pathways, suggesting its involvement in a complex network of cellular signaling. The study of CIRH1A recombinant proteins has opened new avenues for understanding its structure-function relationship, enabling researchers to elucidate its biochemical properties and regulatory mechanisms. This research is vital not only for understanding fundamental biological processes but also for developing novel treatments for circadian-related diseases. As studies continue to explore the implications of CIRH1A in health and disease, the development of recombinant proteins will play a crucial role in advancing our knowledge and therapeutic strategies targeting circadian rhythm disorders.
