Analytical Data
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基因名
CIRH1A
- Application
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别名
UTP4; CIRH1A; cPERP-E; KIAA1988U3 small nucleolar RNA-associated protein 4 homolog; Cirhin; UTP4 small subunit processome component
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q969X6
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表达区间
1-686aa
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氨基酸序列
MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT
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分子量
101.2 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CIRH1A, or circadian rhythm-1A, is a protein that has garnered significant attention in recent years due to its crucial role in circadian rhythms and cellular functions. It is primarily involved in the regulation of gene expression related to the circadian clock, influencing various physiological processes including sleep-wake cycles, hormone secretion, and metabolic functions. Disruption of CIRH1A function has been implicated in various disorders such as sleep disorders, metabolic syndromes, and even certain types of cancer, highlighting its potential as a therapeutic target. Additionally, CIRH1A interacts with numerous proteins and pathways, suggesting its involvement in a complex network of cellular signaling. The study of CIRH1A recombinant proteins has opened new avenues for understanding its structure-function relationship, enabling researchers to elucidate its biochemical properties and regulatory mechanisms. This research is vital not only for understanding fundamental biological processes but also for developing novel treatments for circadian-related diseases. As studies continue to explore the implications of CIRH1A in health and disease, the development of recombinant proteins will play a crucial role in advancing our knowledge and therapeutic strategies targeting circadian rhythm disorders.
