Analytical Data
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基因名
CIR
- Application
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别名
KCNJ5; GIRK4; G protein-activated inward rectifier potassium channel 4; GIRK-4; Cardiac inward rectifier; CIR
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48544
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表达区间
1-450aa
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氨基酸序列
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE
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分子量
78.7 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CIR (Cytoplasmic Inhibitor of Recombination) protein has garnered significant interest in the field of molecular biology due to its pivotal role in DNA repair and recombination processes. Its primary function is to regulate the activity of proteins involved in homologous recombination, a critical mechanism for maintaining genomic stability and facilitating proper DNA repair, particularly during cellular stress conditions such as DNA damage. Research indicates that the dysfunction or dysregulation of CIR can lead to increased susceptibility to genomic instability and has been implicated in various diseases, including cancer. Understanding the structure and function of CIR not only sheds light on fundamental cellular processes but also opens potential avenues for therapeutic interventions. By elucidating the molecular mechanisms through which CIR exerts its effects, scientists aim to develop novel strategies for enhancing DNA repair pathways in cancer therapy and improving the efficacy of existing treatments. This research potentially contributes to the development of biomolecular techniques that can manipulate CIR activity for improved patient outcomes, highlighting its significance in both basic research and clinical applications.
