Analytical Data
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基因名
SCN2B
- Application
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别名
SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60939
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表达区间
1-215 aa
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氨基酸序列
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
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分子量
49.39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCN2B is a gene encoding the beta-2 subunit of voltage-gated sodium channels, which play a crucial role in the propagation of action potentials in neurons. Mutations in SCN2B have been implicated in various neurological disorders, including epilepsy, autism spectrum disorders, and other neurodevelopmental conditions. The research surrounding SCN2B recombinant proteins has gained momentum due to their potential in understanding the physiological and pathological roles of sodium channels in neuronal excitability. By producing and studying these recombinant proteins, researchers aim to elucidate the functional mechanisms of SCN2B and its interaction with the alpha subunits of sodium channels. This understanding is essential for developing targeted therapies for sodium channel-related disorders. Moreover, the investigation of SCN2B’s contributions to channel gating, ion permeability, and modulation by auxiliary proteins could provide insights into the intricate signaling networks in the nervous system. Overall, the study of SCN2B recombinant proteins represents a promising avenue for advancing our knowledge of neuronal function and developing innovative therapeutic strategies for neurological diseases.
