Analytical Data
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Gene name
ACE2
- Application
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Alternative Names
ACE2；Angiotensin-converting enzyme 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYF1
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Expression Region
18-615aa
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AA Sequence
QSTIEEQAKT FLDKFNHEAE DLFYQSSLAS WNYNTNITEE NVQNMNNAGD KWSAFLKEQS TLAQMYPLQE IQNLTVKLQL QALQQNGSSV LSEDKSKRLN TILNTMSTIY STGKVCNPDN PQECLLLEPG LNEIMANSLD YNERLWAWES WRSEVGKQLR PLYEEYVVLK NEMARANHYE DYGDYWRGDY EVNGVDGYDY SRGQLIEDVE HTFEEIKPLY EHLHAYVRAK LMNAYPSYIS PIGCLPAHLL GDMWGRFWTN LYSLTVPFGQ KPNIDVTDAM VDQAWDAQRI FKEAEKFFVS VGLPNMTQGF WENSMLTDPG NVQKAVCHPT AWDLGKGDFR ILMCTKVTMD DFLTAHHEMG HIQYDMAYAA QPFLLRNGAN EGFHEAVGEI MSLSAATPKH LKSIGLLSPD FQEDNETEIN FLLKQALTIV GTLPFTYMLE KWRWMVFKGE IPKDQWMKKW WEMKREIVGV VEPVPHDETY CDPASLFHVS NDYSFIRYYT RTLYQFQFQE ALCQAAKHEG PLHKCDISNS TEAGQKLFNM LRLGKSEPWT LALENVVGAK NMNVRPLLNY FEPLFTWLKD QNKNSFVGWS TDWSPYADGG GGSGGGGSDK THTCPPCPAP EAAGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
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Molecular Weight
190 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Angiotensin-converting enzyme 2 (ACE2) is a pivotal enzyme in the renin-angiotensin system, playing a critical role in cardiovascular and respiratory health. Its primary function involves hydrolyzing angiotensin II, a peptide associated with vasoconstriction and blood pressure regulation, into angiotensin-(1-7), which has protective cardiovascular effects. The significance of ACE2 became particularly pronounced during the COVID-19 pandemic, as SARS-CoV-2, the virus responsible for COVID-19, utilizes ACE2 as its entry receptor. This interaction has prompted extensive research into the expression and function of ACE2 in various tissues, especially lung, heart, and kidney. Scientists are investigating ACE2 recombinant proteins to better understand its mechanisms and potential therapeutic applications. These recombinant proteins are employed in assays and research to explore ACE2's role in viral entry, inflammation, and its protective effects against acute lung injury and other complications. Additionally, ACE2 therapeutics, such as recombinant ACE2 or ACE2 mimetics, are being studied for their potential to mitigate the effects of COVID-19 and related diseases by restoring balance in the renin-angiotensin system. Ongoing research aims to elucidate ACE2's broader implications in health and disease, paving the way for innovative treatments that target ACE2 to enhance cardiovascular and pulmonary function, especially in the context of viral infections and hypertension.
