Analytical Data
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基因名
MARCO
- Application
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别名
MARCO；SCARA2；Macrophage receptor MARCO
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q60754
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表达区间
70-518aa
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氨基酸序列
QVLNLQEQLQ MLEMCCGNGS LAIEDKPFFS LQWAPKTHLV PRAQGLQALQ AQLSWVHTSQ EQLRQQFNNL TQNPELFQIK GERGSPGPKG APGAPGIPGL PGPAAEKGEK GAAGRDGTPG VQGPQGPPGS KGEAGLQGLT GAPGKQGATG APGPRGEKGS KGDIGLTGPK GEHGTKGDKG DLGLPGNKGD MGMKGDTGPM GSPGAQGGKG DAGKPGLPGL AGSPGVKGDQ GKPGVQGVPG PQGAPGLSGA KGEPGRTGLP GPAGPPGIAG NPGIAGVKGS KGDTGIQGQK GTKGESGVPG LVGRKGDTGS PGLAGPKGEP GRVGQKGDPG MKGSSGQQGQ KGEKGQKGES FQRVRIMGGT NRGRAEVYYN NEWGTICDDD WDNNDATVFC RMLGYSRGRA LSSYGGGSGN IWLDNVNCRG TENSLWDCSK NSWGNHNCVH NEDAGVECS
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MARCO (macrophage receptor with collagenous structure) is a class B scavenger receptor predominantly expressed on macrophages, playing a crucial role in the immune response and homeostasis. Initially identified for its ability to bind and internalize collagens and other extracellular matrix components, recent studies have elucidated its multifaceted functions in innate immunity, inflammation, and tissue remodeling. MARCO is instrumental in the phagocytic clearance of pathogens, contributing to the host defense against infections. Additionally, it has been implicated in modulating inflammatory responses, as its expression can be upregulated in response to inflammatory stimuli. Given its pivotal role in regulating macrophage function, MARCO has emerged as a potential therapeutic target for various diseases, including chronic inflammatory conditions, atherosclerosis, and cancer. Understanding the molecular mechanisms underlying MARCO's interactions with ligands and its signaling pathways is crucial for developing novel strategies to manipulate macrophage activity for therapeutic benefits. Thus, ongoing research aims to dissect the structural and functional properties of MARCO, which may pave the way for innovative biomedical applications in enhancing immune responses or mitigating pathological inflammation.
