Analytical Data
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Gene name
SARA2
- Application
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Alternative Names
Small COPII coat GTPase SAR1B. EC:3.6.5.2. GTP-binding protein B. GTBPB. Secretion-associated Ras-related GTPase 1B
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6B6
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Expression Region
1-198 aa
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AA Sequence
MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSVLKRQGYGEGFRWMAQYID
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Molecular Weight
47.52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SARA2, a protein involved in various cellular processes, has garnered significant attention in the field of molecular biology due to its crucial role in signal transduction and cellular homeostasis. It is known to interact with key intracellular pathways, influencing cellular responses to environmental cues. Research on SARA2 has highlighted its importance in the regulation of stem cell differentiation, apoptosis, and immune responses. Recent studies have focused on its potential implications in cancer biology, where aberrant expression of SARA2 may contribute to tumor progression and resistance to therapy. Understanding the structure and function of SARA2 through recombinant protein studies is vital for elucidating its mechanisms of action. Advances in recombinant protein technology allow for the production of SARA2 in a controlled environment, enabling detailed biochemical and biophysical characterization. This research can pave the way for novel therapeutic strategies targeting SARA2-related pathways, making it a promising candidate in drug discovery. Moreover, studying SARA2 in various model systems enhances our comprehension of its biological roles, thereby providing insights into its potential as a biomarker for disease states. Overall, the investigation of SARA2 as a recombinant protein holds great promise for advancing our understanding of cellular dynamics and developing innovative treatments for diseases associated with its dysregulation.
