Analytical Data
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Gene name
SARA1
- Application
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Alternative Names
COPII associated small GTPase; COPII-associated small GTPase; GTP binding protein SAR1a; GTP-binding protein SAR1a; Masra 2; Masra2; SAR 1; SAR1 gene homolog A; SAR1 homolog A (S. cerevisiae); SAR1A; SAR1a gene homolog (S cerevisiae) 1; SAR1a gene homolog 1 (S cerevisiae); SAR1a gene homolog 1; SAR1A_HUMAN; SARA 1; Sara; SARA1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NR31
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Expression Region
1-198 aa
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AA Sequence
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID
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Molecular Weight
49.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SARA1, or Smad Anchor for Receptor Activation 1, is a critical molecule that plays a pivotal role in the transforming growth factor-beta (TGF-β) signaling pathway, which is essential for various cellular processes, including growth, differentiation, and apoptosis. Dysregulation of this pathway is implicated in numerous diseases, including cancer and fibrosis. The study of SARA1 and its interactions has garnered attention due to its function as a scaffolding protein that helps in the localization and activation of Smad proteins, key transducers in the TGF-β signaling cascade. Research has focused on understanding the structural and functional characteristics of SARA1, including its binding interactions with receptor complexes and Smads, to elucidate its role in cellular signaling. Furthermore, the production of recombinant SARA1 protein has facilitated comprehensive in vitro studies, enabling scientists to explore its biochemical properties and potential therapeutic applications. By unraveling the complexities of SARA1, researchers aim to gain deeper insights into TGF-β signaling and its contributions to disease mechanisms, ultimately contributing to the development of targeted interventions for related pathologies.
