Analytical Data
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Gene name
ALS3
- Application
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Alternative Names
ALS3；ALS10；ALS8；Agglutinin-like Protein 3
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Species
E.coli
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q59L12
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Expression Region
18-330aa
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AA Sequence
KTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVAT
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Molecular Weight
40.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ALS3, a gene found in the fungus *Candida albicans*, encodes a surface protein that plays a critical role in the pathogen's adherence to host tissues and the development of biofilms. This protein is particularly significant because *Candida albicans* is a common opportunistic pathogen responsible for infections in immunocompromised individuals. Research into ALS3 has gained momentum due to its potential implications in understanding the mechanisms of fungal virulence and host-pathogen interactions. The importance of ALS3 is underscored by its involvement in the morphological switch from yeast to hyphal forms, a key factor in the pathogenicity of *Candida albicans*. Studies have shown that ALS3-mediated adhesion enhances the organism's ability to colonize and affect various tissues, leading to both localized and systemic infections. Moreover, the surface localization of ALS3 makes it a target for vaccine development and novel therapeutic strategies, aiming to disrupt its function and render the pathogen less virulent. By generating recombinant ALS3 protein for immunological studies and potential vaccine formulation, researchers hope to elucidate its role in pathogenesis and develop innovative approaches to combat *Candida albicans* infections. Understanding the interactions between ALS3 and host immune responses could pave the way for better therapeutic interventions and contribute to the broader field of antifungal drug discovery. Overall, the investigation of ALS3 and its recombinant protein forms holds significant promise for advancing our knowledge of fungal biology and improving clinical outcomes for patients suffering from fungal infections.
