Analytical Data
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基因名
CEP120
- Application
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别名
CCDC100; CE120_HUMAN; Centrosomal Protein of 120 kDa; Cep120; Coiled-coil domain-containing Protein 100
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N960
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表达区间
1-380aa
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氨基酸序列
MVSKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKALHQHRLQRTPIKLQCFALDPVTSAKETIGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKSEIQISIALETDTKPPVDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVTIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLCCGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQREGIDSQDAFWYSALDIIFPLFIFLFLVLDAIRKFANYEEK
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分子量
69.1 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CEP120, a protein encoded by the CEP120 gene, plays a crucial role in the formation and maintenance of cilia, microtubule-based organelles found on the surface of many eukaryotic cells. Research suggests that CEP120 is involved in the assembly of the ciliary axoneme, a structure critical for ciliary function. Mutations in the CEP120 gene have been associated with various ciliopathies, a group of genetic disorders that arise from dysfunction in cilia, leading to a range of clinical manifestations such as retinitis pigmentosa, nephronophthisis, and skeletal abnormalities. Understanding the molecular mechanisms underlying CEP120 function can provide insights into the pathogenesis of these ciliopathies and may identify potential therapeutic targets for treatment. Recent studies have focused on characterizing the interactions of CEP120 with other proteins involved in the ciliary assembly process and exploring its role in the regulation of centrosome dynamics. Furthermore, advances in imaging techniques and genetic editing tools have facilitated the in-depth examination of CEP120’s function in cellular models, highlighting its importance in ciliary biogenesis and cellular signaling pathways. As research continues to elucidate the complex biological roles of CEP120, it holds promise for advancing our knowledge of cilia-related diseases and developing innovative interventions.
