Analytical Data
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Gene name
CAMK1
- Application
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Alternative Names
CAMK1；Calcium/calmodulin-dependent Protein kinase type 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14012
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Expression Region
1-370aa
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AA Sequence
MLGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC IAKEALEGKE GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG GELFDRIVEK GFYTERDASR LIFQVLDAVK YLHDLGIVHR DLKPENLLYY SLDEDSKIMI SDFGLSKMED PGSVLSTACG TPGYVAPEVL AQKPYSKAVD CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP YWDDISDSAK DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TASHGELLTP VAGGPAAGCC CRDCCVEPGT ELSPTLPHQL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAMK1, or calcium/calmodulin-dependent protein kinase 1, is a serine/threonine protein kinase that plays a critical role in various cellular processes, including signal transduction, gene expression, and cell proliferation. Given its pivotal involvement in mediating calcium signaling pathways, CAMK1 has attracted significant research interest, particularly in the context of neurological disorders and cardiac function. Dysregulation of CAMK1 activity has been linked to several diseases, including neurodegenerative conditions, cancer, and cardiovascular diseases. The study of recombinant CAMK1 protein provides valuable insights into its functional mechanisms and regulatory pathways. By producing and characterizing this protein in a recombinant system, researchers can investigate the kinase's enzymatic properties, interaction with substrates, and potential as a therapeutic target. Additionally, elucidating the structure and dynamics of CAMK1 through techniques such as X-ray crystallography and NMR spectroscopy is crucial for understanding its role in cellular signaling. Developing inhibitors or modulators of CAMK1 could lead to novel treatment strategies for diseases associated with its dysfunction. Overall, the exploration of CAMK1 as a recombinant protein contributes to a deeper understanding of calcium signaling and its implications in health and disease.
