Analytical Data
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Gene name
SAFB2
- Application
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Alternative Names
DKFZP779C1727; HAP; HET; hsp27 ere tata binding; KIAA0138 ; SAF B; SAF B2 ; SAF-B2; SAFB; SAFB1; SAFB2; SAFB2_HUMAN; Scaffold attachment factor B2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14151
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Expression Region
1-528 aa
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AA Sequence
MAETLPGSGDSGPGTASLGPGVAETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIELEATSKKSAKRCVKGLKMEEEGTEDNGLEDDSRDGQEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGLLDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVEIKIEKTVIKKEEM
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Molecular Weight
83.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SAFB2 (SAF-B2) is a member of the Scaffold Attachment Factor (SAF) family, involved in various cellular processes, including gene regulation, RNA processing, and chromatin remodeling. Its role in nuclear mRNA export and its interactions with proteins involved in transcriptional regulation make it a critical player in maintaining cellular homeostasis. Recent studies have identified SAFB2 as a potential biomarker in several diseases, including cancer, where it has been linked to tumor progression and poor prognosis. The understanding of SAFB2's molecular mechanisms and its interactions with other proteins is still evolving, presenting challenges due to its multifunctional nature. The recombinant expression and characterization of SAFB2 protein are essential for elucidating its structure-function relationships and for developing therapeutic strategies targeting its pathways. Researchers aim to produce high-purity, functional SAFB2 recombinant protein to study its role in cellular mechanisms and its potential interplay with therapeutic agents. Additionally, these studies can provide insights into signal transduction pathways that may be altered in disease contexts and help identify novel targets for intervention in diseases where SAFB2 plays a significant role. Consequently, understanding SAFB2 not only contributes to the basic knowledge of cellular biology but also opens avenues for innovative therapeutic approaches in diseases associated with its dysregulation.
