Analytical Data
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Gene name
CECR5
- Application
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Alternative Names
A930002G03Rik; Cat eye syndrome chromosome region. candidate 5; Cat eye syndrome chromosome region. candidate 5 homolog; Cat eye syndrome critical region Protein 5; Cecr5; CECR5_HUMAN; MGC25951; OTTMUSP00000025905
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXW7
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Expression Region
24-423aa
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AA Sequence
AAGLQGRPARRCYAVGPAQSPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRLKTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKVTGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSCISILVCTGVYNPRNPQSTEPVLGGGEPPFHGHRDLCFSPGLMEASHVVNDVNEAVQLVFRKEGWALE
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Molecular Weight
69.74 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The C-C chemokine receptor type 5 (CCR5) is a crucial co-receptor that facilitates the entry of certain viruses, particularly HIV, into host cells, making it a key focus in HIV research and therapeutic interventions. Understanding the structure and function of CCR5 offers insight into its role in immune response and disease progression. Researchers have developed recombinant CCR5 proteins to investigate the receptor's biochemical properties, binding interactions, and underlying mechanisms of viral entry. These studies have provided valuable data on CCR5's conformational changes upon ligand binding and have paved the way for the design of small molecule antagonists and monoclonal antibodies aimed at blocking HIV entry. Moreover, CCR5 has also been implicated in various inflammatory conditions, underscoring the potential therapeutic applications of CCR5-targeting agents beyond virology. The generation and characterization of CCR5 recombinant proteins are vital for high-throughput screening of novel therapeutic compounds and for the development of vaccines, further emphasizing CCR5's importance in both basic research and clinical applications. Thus, the study of CCR5 recombinant proteins not only enhances our understanding of HIV pathogenesis but also opens avenues for innovative strategies to combat a range of diseases where CCR5 plays a significant role.
