Analytical Data
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基因名
CECR5
- Application
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别名
A930002G03Rik; Cat eye syndrome chromosome region. candidate 5; Cat eye syndrome chromosome region. candidate 5 homolog; Cat eye syndrome critical region Protein 5; Cecr5; CECR5_HUMAN; MGC25951; OTTMUSP00000025905
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BXW7
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表达区间
24-423aa
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氨基酸序列
AAGLQGRPARRCYAVGPAQSPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRLKTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKVTGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSCISILVCTGVYNPRNPQSTEPVLGGGEPPFHGHRDLCFSPGLMEASHVVNDVNEAVQLVFRKEGWALE
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分子量
69.74 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The C-C chemokine receptor type 5 (CCR5) is a crucial co-receptor that facilitates the entry of certain viruses, particularly HIV, into host cells, making it a key focus in HIV research and therapeutic interventions. Understanding the structure and function of CCR5 offers insight into its role in immune response and disease progression. Researchers have developed recombinant CCR5 proteins to investigate the receptor's biochemical properties, binding interactions, and underlying mechanisms of viral entry. These studies have provided valuable data on CCR5's conformational changes upon ligand binding and have paved the way for the design of small molecule antagonists and monoclonal antibodies aimed at blocking HIV entry. Moreover, CCR5 has also been implicated in various inflammatory conditions, underscoring the potential therapeutic applications of CCR5-targeting agents beyond virology. The generation and characterization of CCR5 recombinant proteins are vital for high-throughput screening of novel therapeutic compounds and for the development of vaccines, further emphasizing CCR5's importance in both basic research and clinical applications. Thus, the study of CCR5 recombinant proteins not only enhances our understanding of HIV pathogenesis but also opens avenues for innovative strategies to combat a range of diseases where CCR5 plays a significant role.
