Analytical Data
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基因名
SACM1L
- Application
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别名
SACM1L; KIAA0851; SAC1; Phosphatidylinositol-3-phosphatase SAC1; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NTJ5
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表达区间
1-587 aa
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氨基酸序列
MATAAYEQLKLHITPEKFYVEACDDGADDVLTIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIFKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVDAPRLVQKEKID
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分子量
93.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SACM1L, or Sac1-like phosphoinositide phosphatase SACM, is an emerging protein of interest in cellular biology due to its role in lipid metabolism and membrane dynamics. Recent studies have highlighted its importance in regulating phosphoinositides, which are crucial for various cellular processes including signal transduction, cytoskeletal organization, and vesicular trafficking. Dysfunctional SACM1L has been linked to several pathological conditions, including cancer and neurodegenerative diseases, making it a potential target for therapeutic interventions. Recombination techniques to produce SACM1L protein provide valuable insights into its structure-function relationships and mechanisms of action. These recombinant proteins can be used for a variety of biophysical and biochemical assays to elucidate SACM1L's role in cellular signaling pathways. Understanding SACM1L’s functional mechanisms is critical for identifying new therapeutic strategies aimed at modulating its activity in disease contexts. Moreover, the study of SACM1L may pave the way for exploring its interactions with other cellular proteins, contributing to a more holistic understanding of lipid metabolism and related disorders. Thus, research into the recombinant expression and functional characterization of SACM1L not only enhances our comprehension of its biological role but also opens new avenues for innovative biomedical applications.
