Analytical Data
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Gene name
TBG
- Application
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Alternative Names
TBG；TBG；Thyroxine-binding globulin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05543
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Expression Region
1-415aa
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AA Sequence
MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFA FNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNL TDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDV KTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVL VNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDM ELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGW VDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAA HKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERST RSILFLGKVVNPTEA
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Molecular Weight
73 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on TBG (Thyroxine-Binding Globulin) recombinant proteins is rooted in the need to understand and manipulate thyroid hormone transport and metabolism in the human body. TBG is a crucial plasma protein responsible for binding and transporting thyroxine (T4) and triiodothyronine (T3), which are essential hormones regulating metabolism, growth, and development. Abnormal levels of TBG can lead to thyroid disorders, including hypothyroidism and hyperthyroidism, making its study significant for clinical diagnostics and therapies. The advent of recombinant DNA technology has enabled the production of TBG in the laboratory, allowing for better characterization of its structure and function, as well as the investigation of genetic variants associated with thyroid hormone transport disorders. Furthermore, recombinant TBG can serve as a valuable tool in research and therapeutic applications, including the development of hormone replacement therapies and the study of drug interactions that influence thyroid hormone levels. By focusing on TBG, researchers aim to enhance understanding of thyroid health and develop novel approaches for managing thyroid-related diseases, ultimately contributing to improved patient outcomes in endocrinology.
