Analytical Data
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基因名
KCT2
- Application
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别名
KCT2；C5orf15；Keratinocyte-associated transmembrane Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NC54
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表达区间
1-196aa
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氨基酸序列
MAAAVPKRMR GPAQAKLLPG SAIQALVGLA RPLVLALLLV SAALSSVVSR TDSPSPTVLN SHISTPNVNA LTHENQTKPS ISQISTTLPP TTSTKKSGGA SVVPHPSPTP LSQEEADNNE DPSIEEEDLL MLNSSPSTAK DTLDNGDYGE PDYDWTTGPR DDDESDDTLE ENRGYMEIEQ SVKSFKMPSS NIEEED
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCT2, a member of the KCNK (two-pore domain potassium channel) family, has garnered attention in recent years due to its significant roles in regulating various physiological processes. This potassium channel is primarily expressed in the central nervous system and is implicated in maintaining resting membrane potential, modulating neuronal excitability, and contributing to the homeostasis of potassium ion concentrations in cells. The study of KCT2 recombinant protein is critical, as it provides insights into the channel's structure-function relationship, regulatory mechanisms, and potential implications in neurological disorders. With advancements in recombinant DNA technology, scientists can produce KCT2 protein in a controlled environment, allowing for detailed biochemical and electrophysiological analyses. Understanding how KCT2 interacts with other cellular proteins and its response to pharmacological agents could reveal new therapeutic targets for conditions such as epilepsy, depression, and other neurodegenerative diseases. Overall, the exploration of KCT2 recombinant proteins stands at the forefront of neurobiology, promising novel insights into potassium channel functionality and its broader implications for brain health and disease.
