Analytical Data
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Gene name
UL48
- Application
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Alternative Names
UL48；ACID1；ARC92；PTOV2；Mediator of RNA polymerase II transcription subunit 25
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P68335
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Expression Region
1-490aa
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AA Sequence
MDLLVDDLFADADGVSPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSGFPTNADMYRECKFLSTLPSDVIDWGDAHVPERSPIDIRAHGDVAFPTLPATRDELPSYYEAMAQFFRGELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRNRDLREMLRTTIADRYYRETARLARVLFLHLYLFLSREILWAAYAEQMMRPDLFDGLCCDLESWRQLACLFQPLMFINGSLTVRGVPVEARRLRELNHIREHLNLPLVRSAAAEEPGAPLTTPPVLQGNQARSSGYFMLLIRAKLDSYSSVATSEGESVMREHAYSRGRTRNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESPSPGMTHDPVSYGALDVDDFEFEQMFTDAMGIDDFGG
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Molecular Weight
61.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UL48 is a crucial viral protein encoded by the human cytomegalovirus (HCMV), a member of the Herpesviridae family, known for its ability to persist in the host and evade the immune system. Research into UL48 is significant due to its implications in viral pathogenesis and potential therapeutic targets. This protein plays a vital role in the assembly and egress of the virus, facilitating the maturation of viral particles and their release from infected cells. Additionally, UL48 interacts with various host cell proteins, altering cellular functions and enhancing viral replication. Understanding the structure and function of UL48 can provide insights into HCMV biology and its interactions with the host immune response. Moreover, since HCMV is associated with severe disease in immunocompromised patients and can lead to congenital infections, elucidating the mechanisms by which UL48 operates could lead to novel antiviral strategies. Therefore, investigating UL48's functionality not only contributes to our comprehension of HCMV pathogenesis but also aids in the development of targeted therapies that may mitigate the viral impact on at-risk populations.
