Analytical Data
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基因名
RGS13
- Application
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别名
AL713991.1; HGNC:9995; MGC17173; OTTMUSP00000022853; OTTMUSP00000022854; Regulator of G protein signalling 13; Regulator of G-protein signaling 13; RGD1562103; RGS 13; RGS13; RGS13_HUMAN; RP11 92K2.1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14921
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表达区间
1-159 aa
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氨基酸序列
MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA YLKMEHSDEN IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN IDSSTRETII RNIQEPTETC FEEAQKIVYM HMERDSYPRF LKSEMYQKLL KTMQSNNSF
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分子量
19.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS13 (Regulator of G protein Signaling 13) is a member of the RGS protein family, which plays a crucial role in the negative regulation of G protein-coupled receptor (GPCR) signaling pathways. The understanding of RGS13 has gained significance due to its involvement in various physiological processes, including immune response, neuronal signaling, and cardiovascular regulation. Notably, RGS13 has been implicated in the modulation of immune cell functions, particularly in B cells, where it influences the signaling pathways that control their activation and differentiation. Research has highlighted its potential role in diseases such as autoimmunity and cancer, prompting interest in the development of RGS13 recombinant proteins for functional studies. Experimental studies utilizing RGS13 recombinant proteins have provided insights into its biochemical properties, structural characteristics, and interaction dynamics with GPCRs and G proteins. Furthermore, these studies pave the way for exploring its therapeutic potential, as targeting RGS13 may offer novel strategies for modulating signaling pathways in various diseases. The generation and characterization of RGS13 recombinant proteins are essential for elucidating its biological functions and mechanisms of action, thereby enhancing our understanding of GPCR signaling and its implications in health and disease.
