Analytical Data
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Gene name
RGS12
- Application
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Alternative Names
RGS12; Regulator of G-protein signaling 12; RGS12
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14924
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Expression Region
1-555 aa
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AA Sequence
MKKHDFAENLPSSLLIIILVIFTLSGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATSFLSLFPKLRATEQMTNVGC
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Molecular Weight
87.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RGS12 (Regulator of G protein Signaling 12) is a member of the RGS protein family, known for its role in regulating G protein-coupled receptor (GPCR) signaling pathways. Dysregulation of GPCR signaling is implicated in various diseases, including cancer and cardiovascular disorders, making RGS12 a potential therapeutic target. Research on RGS12 has revealed its involvement in diverse physiological processes, such as cell proliferation, differentiation, and apoptosis, highlighting its importance in cellular signaling networks. Additionally, RGS12's interactions with other proteins and cellular components suggest it may play a crucial role in intracellular signaling cascades, further underscoring its relevance in disease mechanisms. Given these findings, the study of RGS12 in the form of recombinant proteins is essential for elucidating its functional roles, as well as for exploring its potential as a biomarker or therapeutic target. By producing and characterizing RGS12 recombinant proteins, researchers aim to better understand its interactions and regulatory mechanisms within GPCR signaling pathways, paving the way for novel therapeutic strategies that could intervene in disease progression associated with RGS12 dysregulation.
