Analytical Data
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Gene name
CACNG6
- Application
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Alternative Names
CACNG8; CACNG6; Voltage-dependent calcium channel gamma-8 subunit; Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory Protein gamma-8; TARP gamma-8
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WXS5
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Expression Region
1-260aa
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AA Sequence
MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNTYKANGSAVCEAAHLGLWKACTKRLWQADVPVDRDTCGPAELPGEANCTYFKFFTTGENARIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGHRAT
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Molecular Weight
54.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNG6, also known as calcium channel voltage-dependent gamma-6 subunit, plays a crucial role in regulating L-type calcium channels in various excitable tissues, including the brain and heart. This protein is involved in modulating calcium influx, which is vital for numerous physiological processes such as neurotransmitter release, muscle contraction, and gene expression. Recent studies have implicated CACNG6 in various neurological disorders, including schizophrenia and autism, highlighting its significance in the maintenance of synaptic function. Additionally, its interaction with other subunits of calcium channels suggests it has a complex role in channel assembly and modulation. With advances in recombinant DNA technology, researchers have begun to produce and characterize recombinant CACNG6 proteins to better understand their functional properties and interactions at the molecular level. This research aims to elucidate the specific mechanisms by which CACNG6 influences calcium channel activity and, subsequently, cellular signaling pathways. By characterizing CACNG6 and its functional implications, scientists hope to provide insights into its potential as a therapeutic target for calcium channel-related disorders, paving the way for the development of novel pharmacological interventions. Understanding the structure-function relationships of CACNG6 may also contribute to broader knowledge in the field of calcium signaling and its implications in both normal physiology and disease states.
