Analytical Data
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Gene name
CACNG5
- Application
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Alternative Names
CACNG5; Voltage-dependent calcium channel gamma-5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; Transmembrane AMPAR regulatory Protein gamma-5; TARP gamma-5
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UF02
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Expression Region
1-296aa
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AA Sequence
MSACGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGVIVPQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTEVKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPFWTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHFPPHSSCVLCRPQPREMRQAPAASPSSAVFSL
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Molecular Weight
59.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNG5, a member of the calcium channel ancillary protein family, plays a crucial role in regulating the activity of voltage-gated calcium channels, which are essential for a wide range of physiological processes, including neurotransmitter release, muscle contraction, and cardiac function. Its dysfunction has been implicated in various neurological and cardiovascular diseases, making it a significant target for therapeutic research. The study of CACNG5 recombinant proteins aims to elucidate its structural properties and functional mechanisms in cellular contexts. By expressing CACNG5 in heterologous systems, researchers can analyze its interactions with calcium channels and other associated proteins, shedding light on the molecular basis of calcium signaling pathways. Furthermore, characterizing CACNG5's specific role in health and disease could lead to the development of new treatment strategies for conditions linked to calcium dysregulation. Enhanced understanding of CACNG5 could also provide insights into its potential as a biomarker for certain diseases. Overall, the research on CACNG5 recombinant proteins is pivotal in advancing our knowledge of calcium homeostasis and its implications in various biological processes, representing a vital frontier in medical research.
