Analytical Data
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基因名
MAP2K2
- Application
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别名
MAP2K2；MEK2；MKK2；PRKMK2；Dual specificity mitogen-activated Protein kinase kinase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36507
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表达区间
1-400aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMLARRKPVLPALTINPTIAEGPSPTS EGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERIS ELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECN SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIA VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS FVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELE AIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIV NEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEE VDFAGWLCKTLRLNQPGTPTRTAV
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP2K2, also known as Mitogen-Activated Protein Kinase Kinase 2, is a critical component of the MAPK signaling pathway, which plays a pivotal role in regulating various cellular processes, including proliferation, differentiation, and survival. Dysregulation of the MAPK pathway has been implicated in several diseases, particularly cancers, making MAP2K2 a potential target for therapeutic intervention. Recent studies have highlighted the significance of MAP2K2 in mediating cellular responses to various stimuli and its role in tumorigenesis. The investigation of recombinant MAP2K2 proteins has gained traction in the research community as it allows for a detailed analysis of its biochemical properties, interaction with upstream and downstream signaling partners, and functional implications in cellular contexts. Furthermore, the expression and purification of recombinant MAP2K2 enable researchers to explore its structural attributes and kinase activity, fostering the development of specific inhibitors or modulators that can be utilized in potential cancer therapies. Understanding the mechanistic details of MAP2K2 could provide insights into its role in oncogenic processes and aid in the identification of novel therapeutic strategies aimed at targeting aberrant MAPK signaling pathways in various malignancies. Overall, the study of recombinant MAP2K2 holds significant promise for advancing our understanding of its biological functions and potential applications in targeted therapies.
