Analytical Data
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基因名
CUP1-1
- Application
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别名
CUP1-1；ACE1；Transcriptional activator Protein CUP2
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0CX80
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表达区间
9-61aa
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氨基酸序列
QNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGNKSEETKKSCCSGK
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分子量
32.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CUP1-1, a copper-binding protein found in yeast, serves as a pivotal model for understanding metal homeostasis and stress responses in eukaryotic cells. Its study is rooted in the increasing recognition of the role of metalloproteins in cellular functions and their implications in health and disease. The expression of CUP1-1 is primarily induced by copper exposure, acting as a critical mechanism for detoxifying excess copper and maintaining cellular metal balance. Additionally, CUP1-1 has garnered interest due to its involvement in processes such as oxidative stress response, which is relevant in the context of aging and various neurodegenerative diseases. Researchers have been investigating the structure, function, and regulatory mechanisms of CUP1-1 to elucidate how it coordinates with cellular pathways to mitigate metal toxicity and to explore its potential applications in biotechnology, particularly in bio-remediation and the development of biosensors. Furthermore, as a model system in yeast, studies of CUP1-1 effectively bridge fundamental biological research with practical applications, emphasizing the importance of heavy metal management in living organisms and the environmental implications of metal exposure.
