Analytical Data
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Gene name
PENK
- Application
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Alternative Names
PENK；Proenkephalin-A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01210
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Expression Region
25-97aa
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AA Sequence
ECSQDC ATCSYRLVRP ADINFLACVM ECEGKLPSLK IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PENK, or Preproenkephalin, is a precursor protein that plays a crucial role in the endogenous opioid system, primarily involved in pain modulation, stress response, and neurotransmission. Research into PENK has gained momentum due to its significant implications in various neurobiological processes and psychiatric disorders. Studies have shown that enkephalins, the active peptides derived from PENK, bind to opioid receptors, influencing pain perception and emotional regulation. Furthermore, alterations in PENK expression have been associated with conditions such as addiction, depression, and anxiety, making it a target for potential therapeutic interventions. With advancements in recombinant DNA technology, the ability to produce PENK and its derived peptides has opened new avenues for exploring their physiological roles and therapeutic potential. Understanding the structural and functional aspects of PENK through recombinant protein studies could pave the way for developing novel pain management strategies and treatments for neuropsychiatric disorders, highlighting the protein’s importance in both basic research and clinical applications. As researchers continue to investigate the multifaceted roles of PENK, its significance in the opioid system and potential impacts on health and disease remain an essential focus in modern biomedical research.
