Analytical Data
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基因名
MATN3
- Application
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别名
MATN3；Matrilin-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15232
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表达区间
29-486aa
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氨基酸序列
DPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKINEYGQIHR
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分子量
57.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MATN3, or Matrilin-3, is a member of the matrilin family of extracellular matrix proteins, which play crucial roles in the structural organization and functionality of connective tissues. The study of MATN3 has gained importance due to its implications in various musculoskeletal disorders, particularly in cartilage and bone development. Research indicates that mutations in the MATN3 gene are associated with conditions such as osteoarthritis and other hereditary skeletal dysplasias, which underscores the protein's potential role in maintaining cartilage integrity and homeostasis. MATN3 interacts with other extracellular matrix components, contributing to the formation of a stable cartilage matrix. Moreover, it is involved in cellular processes such as proliferation, differentiation, and apoptosis, marking its significance in tissue repair and regeneration. Understanding the molecular pathways involving MATN3 could elucidate its function in both normal physiology and pathology, opening avenues for potential therapeutic strategies targeting MATN3-related disorders. Thus, ongoing research into MATN3 recombinant proteins aims to further clarify its biological roles and assess their utility in regenerative medicine and targeted therapies for cartilage-related diseases.
