Analytical Data
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基因名
HNRNPM
- Application
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别名
HNRNPM；HNRPM；NAGR1；Heterogeneous nuclear ribonucleoProtein M
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P52272
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表达区间
2-730aa
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氨基酸序列
AAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKE KNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYV ELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGE HARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGR LGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTF EQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGL GGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEG PFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGI ERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMG SGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPI DRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRM ATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALG AGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARK ACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFES PEVAERACRMMNGMKLSGREIDVRIDRNA
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分子量
93 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M) is a significant member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a critical role in the regulation of pre-mRNA processing, mRNA stability, and transport within the nucleus. Recent studies have highlighted its involvement in various cellular processes, including alternative splicing and response to cellular stress, making it a vital factor in gene expression regulation. Moreover, HNRNPM has been implicated in various pathophysiological conditions, including cancer, neurodegenerative diseases, and viral infections, as it interacts with numerous RNA and protein partners. The recombinant expression of HNRNPM not only facilitates the study of its structure-function relationships but also aids in elucidating its interactions with RNA and other proteins. By producing HNRNPM in a controlled environment, researchers can investigate its role in splicing mechanisms and its contributions to disease pathology. The advancement of techniques such as CRISPR/Cas9 and RNA-seq has further enhanced our ability to dissect HNRNPM's functions and regulatory pathways, providing valuable insights into its potential as a therapeutic target. As our understanding of HNRNPM continues to evolve, the development of HNRNPM recombinant proteins promises to open new avenues for research and application in molecular biology and medicine.
