Analytical Data
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Gene name
GZMD
- Application
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Alternative Names
GZMD；Granzyme D
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11033
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Expression Region
21-252aa
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AA Sequence
IIGGHVVKPH SRPYMAFVMS VDIKGNRIYC GGFLIQDDFV LTAAHCKNSS VQSSMTVTLG AHNITAKEET QQIIPVAKDI PHPDYNATIF YSDIMLLKLE SKAKRTKAVR PLKLPRSNAR VKPGDVCSVA GWGSRSINDT KASARLREVQ LVIQEDEECK KRFRYYTETT EICAGDLKKI KTPFKGDSGG PLVCDNQAYG LFAYAKNGTI SSGIFTKVVH FLPWISWNMK LL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GzMD, or G-protein coupled receptor (GPCR)-modulating disulfide bond-containing protein, is a novel class of proteins that has garnered significant interest in the fields of molecular biology and pharmacology due to its potential therapeutic applications. As GPCRs play a crucial role in various physiological processes and are prominent targets in drug development, understanding the modulation mechanisms of GzMD can provide insights into GPCR signaling pathways. The research surrounding GzMD primarily focuses on its structure-function relationships, where the presence of disulfide bonds is believed to be pivotal in maintaining protein stability and modulating receptor activity. Investigating the interactions between GzMD and specific GPCRs has the potential to reveal novel regulatory mechanisms and may lead to the development of new pharmacological agents that target these pathways more effectively. Furthermore, elucidating the role of GzMD in cellular processes could open avenues for understanding disease mechanisms, particularly in disorders linked to dysregulated GPCR signaling. Thus, the study of GzMD is positioned at the intersection of basic research and drug discovery, making it a compelling topic for exploration in the quest for innovative treatments for a range of diseases.
