Analytical Data
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基因名
Hist1h2bm
- Application
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别名
Hist1h2bm；H2BFE；HIST1H2BM；Histone H2B type 1-M
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99879
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表达区间
2-126aa
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氨基酸序列
PEPVKSAPV PKKGSKKAIN KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK
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分子量
13.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone proteins, including Hist1h2bm, play a crucial role in the structure and function of chromatin, impacting gene expression and DNA replication. Hist1h2bm, a member of the histone H2B family, is essential for the formation of nucleosomes, the fundamental units of chromatin. The study of Hist1h2bm recombinant proteins has gained importance in understanding epigenetic regulation and chromatin remodeling, which are vital for various cellular processes such as transcription, replication, and repair. Alterations in histone modifications, including methylation and acetylation, have been implicated in numerous diseases, including cancer. Research focusing on Hist1h2bm can provide insights into how specific histone variants influence chromatin dynamics and gene regulation. By analyzing the structural and functional properties of recombinant Hist1h2bm, scientists aim to unravel its precise role within the chromatin context, explore its interaction with other nuclear proteins, and investigate how these interactions affect cellular functions. Additionally, studies involving this protein can contribute to the development of epigenetic therapies, providing potential avenues for treating diseases linked to dysregulated histone modification patterns. Overall, understanding Hist1h2bm and its functions is crucial for elucidating the complex mechanisms of gene regulation and chromatin organization in health and disease.
