Analytical Data
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Gene name
PTPRN
- Application
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Alternative Names
PTPRN；ICA3；ICA512；Receptor-type tyrosine-Protein phosphatase-like N
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16849
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Expression Region
35-575aa
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AA Sequence
VSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMR
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Molecular Weight
61.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTPRN, also known as protein tyrosine phosphatase receptor type N, is a member of the receptor-type phosphatase family and plays a crucial role in neuronal signaling and insulin secretion. Dysregulation of PTPRN has been implicated in various diseases, including type 2 diabetes and neurodegenerative disorders such as Alzheimer’s disease. The study of PTPRN is particularly significant because it modulates key cellular processes through the dephosphorylation of tyrosine residues on target proteins, influencing neuronal development, synaptic plasticity, and insulin signaling pathways. Recent research has focused on understanding the structural and functional properties of PTPRN, leading to the development of recombinant proteins that can be utilized for in vitro analyses and therapeutic applications. These recombinant proteins not only aid in elucidating the mechanistic roles of PTPRN in cellular contexts but also provide potential targets for drug development aimed at enhancing or inhibiting its activity in disease states. Therefore, investigating PTPRN recombinant proteins holds promise for unraveling the complex biological functions of this phosphatase and its contributions to health and disease.
