Analytical Data
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Gene name
ARRB1
- Application
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Alternative Names
ARRB1；ARR1；Beta-arrestin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49407
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Expression Region
1-418aa
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AA Sequence
MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARRB1, or Arrestin-1, is a crucial protein involved in cellular signaling processes, particularly in the context of G protein-coupled receptor (GPCR) desensitization and internalization. As an essential component of signal transduction, ARRB1 plays a significant role in various physiological processes, including vision and neuronal signaling. Given its involvement in multiple signaling pathways, ARRB1 has garnered attention in the fields of pharmacology and therapeutic development, especially regarding its potential implications in drug efficacy and the treatment of diseases linked to dysregulated GPCR activity, such as heart disease, cancer, and neurodegenerative disorders. The recombinant expression of ARRB1 allows for the detailed study of its structure, function, and interactions with other proteins, thereby providing insights into its role in cellular signaling. Advances in recombinant protein technology have facilitated the production of ARRB1 in heterologous systems, enabling researchers to investigate its functional properties and to screen for small molecules that may modulate its activity. This enhanced understanding of ARRB1's mechanisms could lead to the development of novel therapeutic strategies that target GPCR-related pathways more effectively, ultimately contributing to improved patient outcomes in a variety of diseases.
