Analytical Data
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基因名
CD86
- Application
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别名
CD86；CD28LG2；T-lymphocyte activation antigen CD86
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42081
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表达区间
26-247aa
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氨基酸序列
APLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKE KFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRI HQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLL RTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETD KTRLLSSPFSIELEDPQPPPDHIP
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分子量
51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD86, also known as B7-2, is a co-stimulatory molecule expressed on antigen-presenting cells (APCs) that plays a critical role in immune regulation and activation. The interaction between CD86 and its receptors, CD28 and CTLA-4 on T cells, is pivotal for effective T cell activation and proliferation. Understanding CD86's role in immune responses is crucial for developing therapeutic strategies for a variety of conditions, including autoimmune diseases, cancers, and infectious diseases. In recent years, recombinant CD86 proteins have garnered attention for their potential applications in immunotherapy and vaccine development. By engineering CD86 as a recombinant protein, researchers can explore its interactions, optimize its biological activity, and assess its therapeutic efficacy in vivo. Studies have shown that modulating CD86 expression can enhance the immune response against tumors, making it a target for cancer immunotherapy. Additionally, recombinant CD86 can be used to create novel vaccines that promote robust T cell responses. The ongoing research in this area aims to elucidate the precise mechanisms of CD86-mediated co-stimulation and to harness its properties for designing improved immunotherapeutic approaches. Overall, the study of recombinant CD86 proteins holds promise in advancing our understanding of immune regulation and fostering innovative treatments for various diseases.
