Analytical Data
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基因名
MLLT3
- Application
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别名
MLLT3；AF9；YEATS3；Protein AF-9
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42568
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表达区间
1-138aa
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氨基酸序列
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKA
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分子量
23.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLLT3 (Myeloid/Lymphoid or Mixed-Lineage Leukemia 3) is a gene involved in chromosomal translocations associated with various hematological malignancies, particularly acute leukemias. The MLLT3 protein, originally identified as a fusion partner in MLL (Mixed-Lineage Leukemia) gene rearrangements, plays a critical role in the regulation of gene expression and hematopoietic differentiation. Its dysregulation is implicated in the pathogenesis of leukemia through mechanisms like altered transcriptional control and disruption of normal cellular signaling pathways. The study of MLLT3 recombinant protein is essential for understanding its functional properties and interactions with other molecular components in the cell. By producing and characterizing recombinant MLLT3, researchers aim to dissect its role in oncogenesis and its potential as a therapeutic target. Investigating the protein’s structure, binding partners, and cellular functions may provide insights into the development of novel treatments for leukemia and improve our ability to diagnose and stratify patients based on specific genetic alterations. Overall, MLLT3 serves as a significant focus in cancer biology, highlighting the intricate connections between chromosomal abnormalities and disease progression.
