Analytical Data
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基因名
POU3F3
- Application
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别名
Brain 1; Brain specific homeobox/POU domain protein 1; Brain-1; Brain-specific homeobox/POU domain protein 1; Brain-specific homeobox/POU domain protein 1.1; Brain1; BRN 1; Brn-1; BRN1; Brn1. mouse. homolog of; class 3; Class III POU domain protein taichi; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF 8; OTF-8; OTF8; PO3 F3; PO3F 3; PO3F3; PO3F3_HUMAN; POU class 3 homeobox 3; POU domain; POU domain protein 12; POU domain. class 3. transcription factor 3; POU domain. class 3. transcription factor 3-A; pou12; POU3 F3; POU3F 3; Pou3f3; RHS 1; Rhs 2; RHS1; Rhs2; Skin 1; Skin1; tai-ji; transcription factor 3; zp12; zp12pou
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20264
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表达区间
1-500 aa
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氨基酸序列
MATAASNPYL PGNSLLAAGS IVHSDAAGAG GGGGGGGGGG GGGAGGGGGG MQPGSAAVTS GAYRGDPSSV KMVQSDFMQG AMAASNGGHM LSHAHQWVTA LPHAAAAAAA AAAAAVEASS PWSGSAVGMA GSPQQPPQPP PPPPQGPDVK GGAGRDDLHA GTALHHRGPP HLGPPPPPPH QGHPGGWGAA AAAAAAAAAA AAAAHLPSMA GGQQPPPQSL LYSQPGGFTV NGMLSAPPGP GGGGGGAGGG AQSLVHPGLV RGDTPELAEH HHHHHHHAHP HPPHPHHAQG PPHHGGGGGG AGPGLNSHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS TGSPTSIDKI AAQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITNLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGIQ QQTPDDVYSQ VGTVSADTPP PHHGLQTSVQ
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分子量
50.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POU3F3, also known as OCT6 or Brn-2, is a member of the POU (POU domain, class 3) family of transcription factors, which play crucial roles in the regulation of gene expression during developmental processes and cellular differentiation. Initially identified for its expression in neural tissues, research indicates that POU3F3 is involved in neuronal differentiation, stem cell maintenance, and pluripotency induction. It has garnered attention due to its potential implications in neurological disorders and its role in the regulation of critical genes associated with cancer stem cells. Overexpression of POU3F3 has been linked to various malignancies, suggesting it may act as an oncogene, further highlighting its importance in cancer biology. The recombinant protein of POU3F3 has been produced for experimental studies to better understand its structure-function relationships, binding mechanisms to target DNA, and interaction with other cellular proteins. This has paved the way for the development of therapeutic strategies aimed at modulating its activity in diseases where its dysregulation is implicated. Understanding the nuances of POU3F3's function and its role in cellular pathways is essential for unlocking new avenues in regenerative medicine and targeted cancer therapies. Thus, ongoing research into the properties and applications of POU3F3 recombinant protein continues to be a significant area of interest in biomedical science.
