Analytical Data
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Gene name
BBS1
- Application
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Alternative Names
BBS2-like Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFJ9
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Expression Region
2-593aa
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AA Sequence
AAASSSDSDACGAESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLGPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA
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Molecular Weight
71.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BBS1 (Bardet-Biedl syndrome 1) is a gene associated with Bardet-Biedl syndrome (BBS), a genetic disorder that affects multiple systems in the body, leading to obesity, retinal dystrophy, and renal abnormalities, among other symptoms. BBS1 is crucial for the functioning of cilia, tiny organelles that play a vital role in cell signaling and development. Research on BBS1 recombinant proteins has gained significance as it provides insight into the molecular mechanisms underlying BBS and related ciliopathies. By expressing and purifying BBS1 recombinantly, scientists can investigate its structural and functional properties, enabling the characterization of its role in cellular processes. Such studies seek to elucidate how mutations in the BBS1 gene contribute to the clinical manifestations of the syndrome, with implications for potential therapeutic interventions. Moreover, recombinant BBS1 proteins can be utilized in drug discovery and development, offering a pathway to identify compounds that could mitigate the effects of BBS1-related dysfunctions. Overall, the study of BBS1 recombinant proteins holds promise for advancing our understanding of ciliary biology and providing new avenues for treating BBS and other ciliopathies.
