Analytical Data
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基因名
CCNK
- Application
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别名
CCNK；CPR4；Cyclin-K
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75909
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表达区间
1-354aa
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氨基酸序列
MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPLILLQGWACRQPATHLLPSPLEDSLLCPRPFPHPACLQLGGWGGQPG
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分子量
42.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCNK (Cyclin C-Dependent Kinase Subunit 2) is a critical protein involved in the regulation of cell cycle progression and transcriptional control. It plays a vital role in the function of cyclin-dependent kinases (CDKs), which are essential for the transition between different phases of the cell cycle. Research on CCNK has gained momentum due to its potential implications in cancer biology, where dysregulation of cell cycle proteins often leads to uncontrolled cell proliferation. Moreover, CCNK has been implicated in various cellular processes, including transcription regulation and DNA damage response, highlighting its importance beyond mere cell cycle control. Studies have focused on understanding the structural and functional properties of CCNK to explore its interactions with other cell cycle regulators and transcription factors. The development of recombinant CCNK proteins allows for detailed biochemical and biophysical analyses, leading to insights into its mechanism of action. Additionally, the investigation of CCNK's roles in oncogenic signaling pathways and its potential as a therapeutic target in cancer treatment has made it an attractive subject for further research. Understanding the precise functions and regulatory mechanisms of CCNK may pave the way for new strategies in cancer therapy and other diseases associated with cell cycle dysregulation.
