Analytical Data
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基因名
PIP5K1B
- Application
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别名
MSS 4; MSS4; Phosphatidylinositol 4 phosphate 5 kinase type 1 beta; Phosphatidylinositol-4-phosphate 5-kinase type I beta; Phosphatidylinositol-4-phosphate 5-kinase type-1 beta; PI4P5K 1 beta; PI51B_HUMAN; PIP5K1-beta; PIP5K1B; PIP5KIbeta; Pipk 5 beta; Pipk 5b; Protein STM 7; Protein STM-7; PtdIns(4)P-5-kinase 1 beta; STM 7; STM7; STM7 LSB; Type I phosphatidylinositol 4 phosphate 5 kinase beta; Type I phosphatidylinositol-4-phosphate 5-kinase beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14986
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表达区间
1-540 aa
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氨基酸序列
MSSAAENGEA APGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRSMRMHF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHFLDHSL KEKEEETPQN VPDAKRTGMQ KVLYSTAMES IQGPGKSGDG IITENPDTMG GIPAKSHRGE KLLLFMGIID ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVNEHY PHDRPTLYSN SKGLPSSSTF TLEEGTIYLT AEPNTLEVQD DNASVLDVYL
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分子量
61.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIP5K1B, or Phosphatidylinositol-4,5-bisphosphate 1-kinase beta, is an important enzyme involved in lipid signaling pathways, particularly in the synthesis of phosphatidylinositol-4,5-bisphosphate (PIP2), a key regulator of various intracellular processes, including cell migration, proliferation, and apoptosis. Aberrant expression or dysfunction of PIP5K1B has been implicated in several diseases, including cancer and neurodegenerative disorders, making it a potential therapeutic target. Research into recombinant PIP5K1B protein aims to elucidate its structure-function relationship, understand the regulatory mechanisms governing its activity, and explore its role in cellular signaling networks. By generating a stable and functional recombinant form of PIP5K1B, scientists can perform detailed biochemical assays, structural characterization, and functional studies to investigate its interaction with other cellular proteins and lipids. These studies are crucial for developing new strategies for modulating PIP5K1B activity in pathological conditions and may contribute to advancing our understanding of phosphoinositide signaling pathways in health and disease. Additionally, recombinant PIP5K1B can serve as a valuable tool for drug screening and identifying small molecules that can selectively inhibit or activate this kinase, ultimately leading to novel therapeutic approaches for diseases associated with its dysregulation.
